Endothelin-2, human

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

由 21 个氨基酸组成的血管活性肽，可与 G 蛋白连接的跨膜受体，ET-RA 和 ET-RB 结合。

Endogenous peptide found predominately in the kidney and intestine. Displays similar selectivity for ETA and ETB endothelin receptors.(In Vitro):At nanomolar concentrations, Endothelin-2 exhibits a strong and long-lasting vasoconstrictor activity characteristic of endothelin (EC50=0.52 nM). Endothelin-2 is a chemoattractant for macrophages and THP-1 monocytic cells, but not for freshly isolated monocytes. The chemotactic response to Endothelin-2 shows a typical bell-shaped response curve. Experiments with endothelin receptor antagonists shows that migration to Endothelin-2 is mediated via the ET-RB receptor. Endothelin-2 expression by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia.(In Vivo):Two distinct phases of pressor effects are typically seen in response to Endothelin-2: the early phase immediately follows the depressor response and dominates during the next 3-10 min, whereas the late pressor effect develops 10-20 min after the injection and lasts >1 hr.

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Endothelin-2 (human, canine); Human endothelin-2

Others

Other Targets

ET-RA, ET-RB

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123562-20-9

2546.92

C115H160N26O32S4

>98% (HPLC)

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Sequence:Cys-Ser-Cys-Ser-Ser-Trp-Leu-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp (Disulfide bridge: Cys1-Cys15, Cys3-Cys11)

(-20℃)

With Ice Pack

≥ 2 years